Endocrine Abstracts

Angiotensin-converting enzyme 2 (ACE2), Transmembrane serine protease 2 (TMPRSS2) and Furin were known to be key players for the SARS-CoV-2 infection. Thyroid gland was shown to be one of the relevant targets for SARS-CoV-2 infection allegedly due to the higher expression levels of these molecules in follicular cells. However, it remains to be fully determined the expression of ACE2, TMPRSS2 and Furin in normal follicular cell. In addition, the putative role of these molecules...

Objectives: RET alterations are targetable oncogenic drivers in TC. Patients with TC, especially those with MTC treated with the multikinase inhibitors cabozantinib and/or vandetanib (C/V), often experience significant treatment-related side effects. Pralsetinib, a selective RET tyrosine kinase inhibitor, showed efficacy in patients with RET-altered TC from the phase 1/2 ARROW trial (NCT03037385). We present the impact of pralsetinib on PROs in patients with ...

Introduction: Parathyroid adenoma is the most frequent cause of primary hyperparathyroidism (PHPT). In recent years minimally invasive surgical techniques have challenged the traditional bilateral neck exploration. There are different imaging techniques for preoperative location of parathyroid adenomas. In this study the authors review the role of Doppler ultrasound focusing on its safety, availability and affordability.Aim: To evaluate the role of Doppl...

IntroductionSARS-CoV2 infection can worsen glycemic control regardless of history of Diabetes mellitus (DM) and may precipitate new-onset diabetes (NOD). DM is also a risk factor for a greater severity of COVID-19. At-admission hyperglycemia (AH) is a known predictor of critical illness in other diseases.AimsAssess the impact of AH, regardless of the presence of DM, on the severity of COVID-19 inpatients....

Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence of 0.7–2.0 per million per year. Prognosis of ACC is generally poor but variable and therapeutic approaches are scarce. While surgical resection presents the best option for definitive cure, mitotane remains the only approved drug for adjuvant therapy in ACC to date. Advancements regarding novel treatment strategies as well as fostered understanding of potential drivers of adrenocortical carcinogenesis ...

Objective: Osteoporosis and vertebral fractures (VFs) are frequently observed in HIV-infected men. Whereas bisphosphonates seem effective on bone mineral density (BMD) maintenance in HIV-men, data on VFs are lacking. We aimed to evaluate the long-term efficacy of bisphosphonates on VFs in HIV-infected men.Design: Real-life longitudinal retrospective study on 118 consecutive HIV-infected males (median age at inclusion 53 years). Median time between first ...

Low plasma sex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represent a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. We have previously determined that fat accumulation reduces SHBG production in different non-alcoholic fatty liver disease (NAFLD) mouse models and that SHBG plays an active role in the development of this disease. In the present work, we are interes...

Fine-Needle Aspiration Biopsy (FNAB) is the recommended diagnostic tool for differentiating malignant from benign thyroid nodules and provides indication for surgical decisions. According to the Italian system, thyroid nodules are classified as TIR 1/1C, TIR 2, TIR 3A, TIR3B, TIR4 or TIR5, which correspond to Thy I, Thy II, Thy III, Thy IV, Thy V and Thy VI categories of the Bethesda system. TIR 3 identifies the indeterminate nodules. Surgery is usually recommended for TIR 3B,...

Endocrine Disrupting Chemicals (EDCs) are a heterogeneous class of compounds so called for their ability to interfere with the endocrine system. These environmental pollutants are detected in different environmental matrices; they can bioaccumulate in adipose tissue and biomagnificate in food chain due to their high hydrophobicity and low water solubility1. Two EDCs usually used in the manufacture of domestic, industrial, and agricultural products are Dibutylphtalat...

Introduction: Polycystic ovary syndrome (PCOS) is a frequent cause of infertility. Its influence on the results of in vitro fertilization (IVF) is controversial, and generally not isolated from the effect of obesity. A relationship between the FSH receptor (FSHR) polymorphism Asn680Ser and the risk and phenotype of PCOS has been studied with conflicting results.Objectives: To analyze the influence of obesity and PCOS on the gonadal axis...